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7,8 Although cellular senescence plays a physiological role in development, its associated pathological changes, such as chronic low-grade systemic inflammation, cartilage thinning, reduced glycosaminoglycan content, altered proteoglycan composition, accumulation of advanced glycation end-products, impaired autophagy, and apoptosis, are key drivers of OA onset and progression

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[DOI] [PMC free article] [PubMed] [Google Scholar] 338.An C., Shi Y., Li P., Hu X., Gan Y., Stetler R.A., Leak R.K., Gao Y., Sun B.L., Zheng P., et al

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